Song Erwei

2012-12-18 00:15
M.D. & Ph.D.
Professor of Breast Surgery
Doctoral Supervisor
President of Sun Yat-sen Memorial Hospital
Dean of Zhongshan School of Medicine
National Yangzi River Scholar in China
Distinguished Professor of China Medical Board (CMB)
Fellow of the Royal Society of Biology (UK)

Clinical Focus
Early Diagnosis of Breast Cancer, Minimally Invasive Treatment of Breast Cancer, Biological Therapy for Breast Cancer, Standard Diagnosis and Treatment of Breast Cancer, which include early diagnosis and treatment that will save both the breasts and armpits, Radical Treatment of Breast Cancer, and Comprehensive Treatment of Late-stage Breast Cancer.


Research Interests
Prof. Song obtained his M.D. and Ph.D. from Sun Yat-sen University, and trained as physician at Sun Yat-sen Memorial Hospital, SYSU. He had postdoc training at Essen University Hospital in Germany and Harvard Medical School from 1999 to 2004. His early publication “RNA interference targeting Fas protects mice from fulminant hepatitis” in Nature Medicine was the first to report that siRNA could be used therapeutically in whole animal disease model, and selected as one of the “Ten breakthroughs of the year 2003” by Science. After setting up his lab at Sun Yat-sen University in China, he has focused his research on the microenvironment of malignant tumors, mainly on breast cancers, and unraveled the regulatory mechanisms of non-coding RNAs (ncRNAs) related to tumor microenvironment.


Academic Achievements
Prof. Song has dedicated himself to the basic research concerning the biology of breast cancer and its therapeutic strategies. His distinguished researches are sponsored by National Science Foundation for Distinguished Young Scholars of China, the State Key Program of National Natural Science of China, A3 Foresight Program by National Natural Science Foundation of China, the Special Program for Key Basic Research of the Ministry of Science and Technology of China, the key Clinical Program of the Ministry of Health of China and the exploratory program of the 863 project. Since 2007, Prof. Song Erwei has led 21 state research projects .


Prof. Song has published 118 research articles in SCI-indexed journals, including Cell, Cancer Cell, Nature Medicine, Nature Biotechnology, Science, Translational Medicine and so on. Also, he is leading five ongoing national research projects, and serves as associate editor for BMC Cancer, Cancer Science and Science China-Life Sciences, and reviewing editor for Journal of Biological Chemistry. He has received numerous honors, including the “Ho Leung Ho Lee Foundation Award” in 2013, and the “National Natural Science Award” by the State Council of China in 2015.


Education /Training
1993,  M.D., Sun-Yat-Sen University of Medical Science, Guangzhou, P.R. China
1995,  M.S., Experimental Surgery, Sun-Yat-Sen University, Guangzhou, P.R. China
2000,  Ph.D., Experimental Hepato-billiary Surgery, Sun-Yat-Sen University,   Guangzhou, P.R. China
2001,  Postdoc Research Fellow, Dept of Transplant Immunology, Essen University Hospital, Essen, Germany.
2003,  Postdoc Research Fellow, CBR Institute of Biomedical Research, Harvard Medical School, Boston, MA, USA.
2004,  Instructor, CBR Institute of Biomedical Research, Harvard Medical School, Boston, MA, USA.


Social Responsibility
2005,  Member, Guangzhou Anti-cancer Association
2005,  Vice Chair, Science and Technology Committee of Guangdong Provincial Jiushan Society
2006,  Standing Committee Member, Young Scientists Association of Guangdong Province
2006,  Vice Chair, Biological and Medical Professional Committee, Young Scientists Association of Guangdong Province
2007,  Standing Member, Guangdong Provincial Jiushan Society
2008,  Standing Committee Member, Breast Disease Division, Guangdong Medical Association
2009,  Executive Council Member, the 3rd Council for Guangdong Anti-cancer Association
2009,  Standing Committee Member, the 6th Committee of Breast Cancer, Chinese Anti-Cancer Association
2010,  Standing Vice Chair (Candidate for Chair), Breast Cancer Committee of Guangdong Province Anti-cancer Association
2012,  Chair, Breast Diseases Division, Guangdong Medical Association
2013,  Vice Chair, Breast Cancer Committee, Chinese Anti-cancer Association
2013,  Member, Guangdong Provincial Committee of Chinese People's Political Consultative Conference
2014,  Standing Committee Member, Surgeon Committee of Chinese Medical Doctor Association
2015,  Vice Chair, the 1st Breast Surgeon Committee of Chinese Medical Doctor Association
2015,  Vice Chair, the 4th Breast Tumor Metastasis Committee of Chinese Anti-cancer Association
2016,  Chair, the 4th Breast Tumor Committee of Guangdong Anti-cancer Association


Representative Publications
1. Song E, Ouyang N, Horbelt M, Antus B, Wang M, Exton MS. Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cellular Immunology 2000; 203: 19-28.                   

2. Song E, Chen J, Antus B, Wang M, Xie Y, Ouyang N, Yao H, Exton MS. Interleukin-2 enhances susceptibility of colon cancer cells to FasR-mediated apoptosis by up-regulating Fas receptor level and down-regulating FAP-1 expression. International Journal of Immunopathology & Pharmacology 2000; 13: 113-22. 
3. Song E, Chen J, Ouyang N, Wang M, Exton MS, Heemann U. Kupffer cells of cirrhotic rat livers sensitize colon cancer cells to Fas-mediated apoptosis. British Journal of Cancer 2001; 84: 1265-71.
4. Song E, Chen J, Ouyang N, Su F, Wang M, Heemann U. Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer. British Journal of Cancer 2001; 85:1047-1054.   
5. Song E, Su F, Chen J, Ou Q, Wang M, Exton MS. Blocking CTL-based cytotoxic pathways reduces apoptosis of transplanted hepatocytes. Journal of Surgical Research 2001; 99:61-9.           

6. Song E, Chen J, Ou Q, Su F. Rare occurrence of metastatic colorectal cancers in livers with replicative hepatitis B infection.  American Journal of Surgery 2001; 181:529-33.                  

7. Song E, Chen J, Antus B, Su F, Wang M, Exton MS. Adenovirus-mediated Bcl-2 gene transfer inhibits apoptosis and promotes survival of allogeneic transplanted hepatocytes. Surgery 2001; 130:502-11.       

8. Song E, Chen J, Lutz J, Wang M, Heemann U. FLIM58, a blocking peptide for FAS ligand, reduces apoptotic cell death of allogenic-transplanted hepatocytes in spleen. Transplantation Proceedings 2001; 33:650.      

9. Song E, Chen J, Su F, Wang M, Heemann U. Granzyme B inhibitor I reduces apoptotic cell death of allogeneic-transplanted hepatocytes in spleen . Transplantation Proceedings 2001; 33: 3274-75.    
10. Antus B, Yao Y, Liu S, Song E, Lutz J, Heemann U. Contribution of androgens to chronic allograft nephropathy is mediated by dihydrotestosterone. Kidney International 2001; 60: 1955-63. 

11. Zhang H, Chen J, Kaiser GM, Mapudengo O, Zhang J, Exton MS, Song E. The value of partial splenic autotransplantation in patients with portal hypertension: a prospective randomized study. Archives of Surgery 2002; 137:89-93.     

12. Antus B, Yao Y, Song E, Liu S, Lutz J, Heemann U. Opposite effects of testosterone and estrogens on chronic allograft nephropathy. Transplantation International 2002; 15: 494-501.

13. Song E, Chen J, Wang K, Zhang H, Su F, Wang M, Heemann U. Intrasplenic transplantation of syngenic hepatocytes modified by IFN-gamma gene ameliorates hepatic fibrosis in rats. Transplantation International 2002; 15: 472-78.  
14. Song E, Yao Y, Antus B, Liu S, Lutz J, Heemann U. Early application of Met-RANTES ameliorates chronic renal rejection. Kidney International 2002; 61:676-85.

15. Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J. RNA interference targeting fas protects mice from fulminant hepatitis. Nature Medicine 2003; 9:347-351. Comments on 266-8.
16. Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, and Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. Journal  of  Virology 2003; 77:7174-81.
17. Lieberman J, Song E, Lee SK, Shankar P. Interfering with Disease:Opportunities and Roadblocks to Harnessing RNA Interference. Trends in Molecular Medicine 2003; 9: 397-403.                                     
18. Su F, Hu X, Jia WJ, Gong C, Song E, Hamar P. Glutathion S Transferase Pi indicates chemotherapy resistance in breast cancer. Journal of Surgical Research 2003; 13:102-8.
19. Wang M, Liu S, Ouyang N, Song E, Lutz J, Heemann U. Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration. Kidney International 2004; 66: 1248-56.

20. Hamar P, Song E, Chen A, Ouyang N, Lieberman J. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proceedings of  the National Academy of Sciences  2004; 101:14883-8.   

21. Yao H*, Song E*, Chen J, Hamar P. Expression of  FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis. British Journal of Cancer 2004; 91: 1718-25.

22. Wang J, Li W, Min J, Ou Q, Chen J, Song E. Intrasplenic transplantation of allogeneic hepatocytes modified by BCL-2 gene protects rats from acute liver failure. Transplantation Proceedings 2004; 36:2924-6.
23. Antus B, Liu S, Yao Y, Zou H, Song E, Lutzs J, Heeman U. Effect of progesterone and oestrogen receptor modulator on chronic allograft nephropathy in rats. Nephrology Dialysis & Transplantation 2005; 20: 329-35.  
24. Su F, Ouyang NY, Zhu P, Ouyang NT, Jia W, Gong C, Ma X, Xu H, Song E. Psychological stress induces chemotherapeutic resistance in breast cancers via upregulating mdr1. Biomedical and Biophysical Research Communications 2005; 329: 888-97.         

25. Lutz J, Yao Y, Song E, Antus B, Hamar P, Liu S, Heemann U. Inhibition of matrix metalloproteinases during chronic allograft nephropathy in rats. Transplantation 2005; 79: 655-61.           

26. Lee SK, Dykxhoorn D, Kumar P, Ranjbar S, Song E, Maliszewski LE, Francois-Bongarcon V, Goldfeld A, Swamy MN, Lieberman J, Shankar P. Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood 2005; 106:818-26.         

27. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn D, Feng Y, Palliser D, Weiner DB, Marasco WA, Shankar P, Lieberman J. Antibody-mediated in vivo delivery of short interfering RNAs via cell surface receptors. Nature Biotechnology 2005; 23:709-17. Comments on 682-4.
28. Gong C*, Song E*, Jia W, Qin L, Guo J, Jia H, Hu X, Su F. A double-blind randomized controlled trial of toremifen therapy for mastalgia. Archives of Surgery 2006; 141: 43-7.          

29. Hu X, Su F, Qin L, Jia W, Gong C, Yu F, Guo J, Song E. Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo. Biochemical and Biophysical Research Communications 2006; 346: 776-85.
30. Xiang Y, Yao H, Wang S, Hong M, He J, Cao S, Min H, Song E, Guo X. Prognostic value of survivin and livin in nasopharyngeal carcinoma. Laryngoscope 2006; 116: 126-30.       

31. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E. let-7 regulates self-renewal and tumorigenesis of breast cancer cells. Cell  2007; 131:1109-23.
32. Min J*, Shang C*, Chen Y, Zhang L, Liu L, Deng X, Yang M, Chen D, Cao J, Song E, Chen J. Selective enrichment of hepatocytes from mouse embryonic stem cells with a culture system containing cholestatic serum. acta pharmacologica sinica . 2007;28(12):1931-7.

33. Pan Q, Wu Y, Lin T, Yao H, Yang Z, Gao G, Song E#, Shen H#. Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene. Biochemical and Biophysical Research Communications. 2009; 379(2):356-61.
34. Li J, Huang H, Sun L, Yang M, Pan C, Chen W, Wu D, Lin Z, Yao Y, Zhang P, Song E. Mir-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clinical Cancer Research 2009; 15:3998-4008.
35. Dykxhoorn  DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J. miR-200 enhances  breast cancer cell colonization to form distant metastases. PLoS One 2009; 4(9):e7181.               

36. Yu F*, Deng H*, Yao H, Liu Q, Su F, Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010; 29:4194-204.
37. Gong C*, Yao H*, Liu Q, Chen J, Shi J, Su F, Song E. Markers of tumor-initiating cells predict chemoresistance in breast cancer. PLoS One 2010; 5(12): e15630.   
38. Mao C, Du J, Sun T, Yao Y, Zhang P, Song E, Wang J. A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy. Biomaterials. 2011;32(11):3124-33. doi: 10.1016/j.biomaterials.2011.01.006. Epub 2011 Jan 28.

39. Sun T *, Du J* , Yao Y *, Mao C, Dou S, Huang S, Zhang P, Kam W. Leong, Song E#, Wang J#. Simultaneous Delivery of siRNA and Paclitaxel via “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression. ACS nano 2011; 5(2):1483-94.
40. Chen J*, Yao Y*, Gong C*, Yu F*, Sun S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Sun F, Karen S. Anderson, Liu Q, Mark E. Ewen, Yao X#, Song E#. CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3. Cancer Cell 2011; 19(4), 541–555.  

41. Long M*, Jia W*, Li S, Jin L, Wu J, Rao N, Feng H, Chen K, Deng H, Liu F, Su F#, Song E#. A single-center, prospective and randomized controlled study: Can the prophylactic use of lamivudine prevent hepatitis B virus reactivation in hepatitis B s-antigen seropositive breast cancer patients during chemotherapy? Breast Cancer Research and Treatment 2011; 127(3):705-12.           

42. Gong C*, Yao Y*, Wang Y, Liu B, Wu W, Chen J, Su F, Yao H#, Song E#. Upregulation of MIR-21 mediates resistance to trastuzumab therapy for breast cancer. Journal of Biological Chemistry 2011; 286(21): 19127-37.   
43. Sun L*, Yao Y*, Liu B, Lin Z, Lin L, Yang M, Zhang W, Chen W, Pan C, Liu Q, Song E#, Li J#. MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene 2012; 31(4): 432-45.


44. Wu G*, Yu F*, Xiao Z, Xu K, Xu J, Tang W, Wang J#, Song E#. Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. British Journal of Cancer 2011; 105(1):146-53.         

45. Yang M, Chen J, Su F, Yu B, Lin L, Liu Y, Huang J#, Song E#. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Molecular Cancer 2011; 10(1):117 .                                          
46. Yu B, Yang M, Wong HY, Watt RM, Song E, Zheng BJ, Yuen KY, Huang JD. A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy. Applied Microbiology and Biotechnolog. 2011; 91(1):177-88. 
47. Zhu Y*, Yu F*, Jiao Y, Feng J, Tang W, Yao H, Gong C, Chen J, Su F, Zhang Y#, Song E#. Reduced miR-128 in breast tumor–initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clinical Cancer Research 2011; 17(22), 7105-15 .
48. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, Zhang W, Tan S, Pandey V, Yao Y, Wang P, Zhao L, Wang J, Wu Q, Song E, Lobie PE, Yin Z, Zhu T. Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Research 2011; 71(20):6463-74.                                             
49. Yu F*, Jiao Y*, Zhu Y*, Wang Y, Zhu J, Cui X, Liu Y, He Y, Park E Y, Zhang H, Lv X, Ma K,  Su F, Park J H#, Song E#. MiR-34c Down-regulation via DNA Methylation Promotes Self-renewal and Epithelial-Mesenchymal Transition in Breast Tumor-Initiating Cells. Journal of Biological Chemistry 2011; 287(1), 465-73 .                                            
50. Chen K*, Zhu L*, Jia W, Rao N, Fan M, Huang H, Shan Q, Han J, Song E, Zeng Y#, Su F#. Validation and comparison of   models to predict nonsentinel lymph node metastasis in breast cancer patients. Cancer Science 2011; 103(2):274-81.

51. Chen K*, Jia W*, Rao N, Deng H, Jin L, Song E, Su F. Assessing second echelon lymph nodes during sentinel lymph node biopsy: Can we have more accurate axillary treatment for breast cancer patients? Medical Hypotheses 2011; 77(6):987-9.

52. He J*, Tang L*, Yu D, Su F, Song E, Lin Y, Wang S, Lai G, Chen W, Ren Z. Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharygeal carcinoma. Cancer Letters 2011; 309:128-36.

53. He J*, Chen L*, Yi S, Cen Y, Tang L, Yu D, Chen W, Wang  Sh, Song E, Ren Z. Joint effects of Epstein-barr virus and polymorphisms in interleukin-10 and interferon-γ on breast cancer risk. Journal of Infectious Diseases 2012; 205: 64-71.
54. Chen L*, Tang L*, He J, Yi S, Cen Y, Yu D, Wu B, Ying L, Chen W, Song E#, Ren Z#. Urinary strontium and the risk of breast cancer: a case-control study in Guangzhou, China. Environmental Research 2012; 112: 212-7.

55. Yao Y*, Sun T*, Huang S, Dou S, Lin L, Chen J, Ruan J, Mao C, Yu F, Zeng M, Zhang J, Liu Q,  Su F, Zhang P, Lieberman J#, Wang J#, Song E#. Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis. Science Translational Medicine 2012; 4:130ra48.

56. Yu S*, Liu Y*, Wang J, Guo Z, Zhang Q, Yu F, Zhang Y, Huang K, Li Y, Song E, Zheng XL, Xiao H. Circulating MicroRNA Profiles as Potential Biomarkers for Diagnosis of Papillary Thyroid Carcinoma. Journal of Clinical Endocrinology and Metabolism. 2012 ; 97(6):2084-92.
57. Dou Sh*, Yao Y*, Yang X, Sun T, Mao Ch, Song E#, Wang J#. Anti-Her2single-chain antibody nediated DNMTs-siRNA delivery for targed breast cancer theray. Journal of Controlled Release. 2012; 161(3):875-83.

58. Gong C, Bauvy C, Tonelli G, Yue W, Delome′nie C, Nicolas V, Zhu Y, Domergue V, Marin-Esteban V, Tharinger H, Delbos L, Gary-Gouy H, Morel A-P, Ghavami S, Song E#, Codogno P# and Mehrpour M#. Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene. 2012 ; doi: 10.1038/onc.2012.252.

59. Gong C, Song E, Codogno P, Mehrpour M.The roles of BECN1 and autophagy in cancer are context dependent. Autophagy. 2012;8(12):1853-5.

60. Liu J*, Deng H*, Jia W, Zeng Y, Rao N, Li S, Jin L, Wu J, Song E#, Su F#. Comparison of ER/PR and HER2 statuses in primary and paired liver metastatic sites of breast carcinoma inpatients with or without treatment. Journal of Cancer Research and Clinical Oncology .2012;138:837-842.

61. Gu R*, Jia W*, Zeng Y*, Rao N, Hu Y, Li S, Wu J, Jin L, Chen L, Long M, Chen K, Chen L, Xiao Q, Wu M, Song E#, Su F#.A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study. BMC Cancer. 2012;12:161. doi: 10.1186/1471-2407-12-161.

62. Li J, Zucker S#, Pulkoski-Gross A, Kuscu C, Karaayvaz M, Ju J, Yao H, Song E, Cao J#. Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking. PLoS One. 2012;7(6):e38403. doi: 10.1371/journal.pone.0038403.

63. Yu B*, Yang M*, Shi L, Yao Y, Jiang Q, Li X, Tang LH, Zheng BJ, Yuen KY, Smith DK, Song E#, Huang JD#. Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain. Scientific Report. 2012;2:436. doi: 10.1038/srep00436.

64. Chen K*, Zeng Y*, Jia H*, Jia W, Yang H, Rao N, Song E, Cox CE#, Su F#.Clinical outcomes of breast-conserving surgery in patients using a modified method for cavity margin assessment. Annals of Surgical Oncology. 2012; 19 (11):3386-94. doi: 10.1245/s10434-012-2331-5.

65. Yang H*, Jia W*, Chen K*, Zeng Y*, Li S, Jin L, Wang L, Song E, Su F. Cavity margins and lumpectomy margins for pathological assessment: Which is superior in breast-conserving surgery? Journal of Surgical Research 2012;178(2):751-7. doi: 10.1016/j.jss.2012.05.030.

66. Nie Y, Liu X, Qu S, Song E, Zou H#, Gong C#. Long noncoding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Science. 2013. doi: 10.1111/cas.12092.

67. Hu H*, Li S*, Cui X, Lv X, Jiao Y, Yu F, Yao H, Song E, Wang M#, Chen Y#, Lin L#. The overexpression of hypomethyl ated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulphate proteoglycan 2 (HSPG2). Journal of Biological Chemistry. 2013;288(16):10973-85.
68. Tang W* ,Yu F* ,Yao H* ,Cui X ,Jiao Y ,Lin L ,Chen J ,Yin D ,Song E ,Liu Q. MiR-27a regulates endothelial differentiation of breast cancer stem like cells,Oncogene. 2013 doi: 10.1038/onc.2013.214.

69. Lv X*, Lian G*, Wang H, Song E, Yao H#, Wang M#.Long Noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One 2013;8(5):e63516. doi: 10.1371

70. Zhu L, Jin L, Li S, Chen K, Jia W, Shan Q, Walter S, Song E#, Su F#.Which nomogram is bestfor predicting non-sentinel lymph node metastasis in breast cancer patients? Ameta-analysis. Breast Cancer Research and Treatment 2013;137(3):783-95.

71. Chen K, Zhu L, Song E, Su F. Re:International Multicenter Tool to Predict the Risk of Nonsentinel Node Metastases in Breast Cancer. J Natl Cancer Inst 2013;105(19):1513-4.
72. Li H, Cui X, Wu W, Yu F, Yao H, Liu Q, Song E, Chen J# .Pyk2 and Src Mediate Signaling to CCL18-Induced Breast Cancer Metastasis. Journal of Cellular Biochemistry  2014 Mar;115(3):596-603.

73. Gong C, Qu S, Liu B, Pan S, Jiao Y, Nie Y, Su F, Liu Q#, Song E#. MiR-106b expression determines the proliferation paradox of TGF-β in breast cancer cells. Oncogene  2013 Dec 2.

74. HE C, SU S, Chen F, Huang D, Zheng F, Huang W, Chen J, Cui X, Liu J, Liu Q, Song E, Yao H and Liu Y, Overexpression of PITPNM3 promotes hepatocellular carcinoma cell metastasis, Chinese Science Bulletin, 2014; 59(12):1326-1333

75. Su S*, Liu Q*, Chen J, Chen J, Chen F, He C, Wu W, Lin L,Li H, Huang D, Huang W, Yu F, Zhang J, Cui X, Zheng F, Yao H, Su F,  Song E. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 2014; 25(5):605-20.

*, # denotes equal contribution

1. Inhibition of gene expression using RNA interfering agents,2004-05-13, International application number:PCT/US2003/034424; International publication number: WO 2004/039957; Published: 2006-12-28, Granted:2010-4-13

2. Methods for treating and preventing apoptosis-related diseases using RNA interfering agents, International application number:PCT/US 2003/034686 , International publication number:WO 2005/013886 , Published: 2007-11-01

3. Method of delivering RNA interference and uses thereof,2006-03-02,International application number:PCT/US2005/029111; International publication number:WO2006/023491 IPC:C07K 16/00 (2006.01), C07H 21/04 (2006.01)  Published: 2008-06-26  , Granted:2012-5-1

4. Let-7 microRNA and mimetics thereof as therapeutics for cancer。2008.8.7,International publish number:WO 2008/095096. International application number:PCT/US2008/052654; Published: 2010-12-09

5. Methods for Treating and Preventing Ischemia-reperfusion Injury Using RNA Interfering Agents, PCT No: PCT/US2004/036200; Pub No: US 2008/0227733A1



Contact Number
Working Time
am 08:00-12:00
pm 14:30-17:30
107 Yan Jiang West Road
P.R. China