唐亚梅

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科研简介

从事神经病学/放射性脑损伤/缺血性脑血管病研究。获国家自然科学基金优秀青年科学基金,入选首届中国十大杰出青年神经内科医师,教育部新世纪优秀人才支持计划。在放射性脑损伤及缺血性脑血管病方向开展了系列研究,发表SCI文章总数23篇(通讯20篇,IF>5分7篇),总他引265次;主编专著2部;研究结果获邀于美国神经科学年会(2014 SfN)、北美脑损伤年会(2009 NABIS)大会发言。

个人简介:

神经科教授、主任医师,博士生导师。现任神经科副主任、神经脑血管病专科副主任。擅长放射性脑损伤、脑梗塞及脑出血、头晕头痛诊治。2019年荣获国家杰出青年科学基金,2016年获国家优秀青年科学基金,曾获首届中国十大杰出青年神经内科医师,教育部新世纪优秀人才。2007年博士毕业于中山大学,同年获选作为中国优秀博士生代表参加第57届诺贝尔获得者大会;曾于美国Medical College of Georgia 进行访问学者研究。近十余年来,带领团队在放射性脑损伤及脑血管病方向开展了系列研究,先后主持国家自然科学基金7项及多项省部级课题;以第一/通讯作者在J Clin Oncol,Acta Neuropathol,Stroke,Neuro Oncol等杂志发表SCI文章33篇(IF>5分10篇,单篇最高28.245),总他引675次;牵头制定《放射性脑损伤诊治中国专家共识》,主编专著3部;研究结果获邀于美国神经科学年会(2019 SfN, 2016 SfN, 2014 SfN)、冷泉港亚洲胶质细胞会议(2016,2018 )大会发言,并获第7届欧洲神经病学大会(7th FENS)优秀学者旅行资助奖励。

个人简历:

1995.09-2002.07中山医科大学七年制硕士

2004.09-2007.06中山大学孙逸仙纪念医院博士

2004.10-2006.10Medical College of Georgia, USA联合培养博士

社会兼职:

广东省医学会脑血管病学分会副主任委员

广东省医学会神经病学分会委员

中国医师协会神经病学分会脑脊髓损害专委会委员

广东省神经药理学会委员

广东省神经病学分会疼痛学组委员

《中华放射医学与防护杂志》编委

教学情况:

承担神经科本科、八年制授课,本科见习带教,指导研究生课题论文工作及论文撰写,分别于2010获评为中山大学优秀临床带教老师,2011获评为中山大学优秀临床教学管理人员,2013年入选“中山大学青年教师重点培育计划”。

科研工作:

作为课题负责人先后承担国家自然科学基金7项(包括国家自然科学基金杰出青年科学基金和优秀青年科学基金),广东省及广州市基金5项。

著作、论文、成果:

一、主编专著

(1)唐亚梅,李艺主编.《鼻咽癌放射治疗神经损伤诊疗规范》北京大学医学出版社 2017.6

(2)唐亚梅,彭英主编.《放射性神经损伤》人民卫生出版社 2012.5

(3)唐亚梅主编.《神经系统放射损伤诊疗手册》人民卫生出版社 2012.11

二、专家共识

《放射性脑损伤诊治中国专家共识》中华神经医学杂志,2019年6月第18卷第6期

三、第一及通讯作者文章(#共同第一,*通讯作者,IF 为2018年杂志影响因子)

1. Jiang J#, Li Y#, Shen Q#, Rong X#, Huang X, Li H, Zhou L, Mai HQ, Zheng D, Chen MY, Xu Y, Li J, Hui X, Simone CB 2nd, Gaertner J, Argyriou AA, Chow E, Chen P, Tang Y*(唐亚梅). Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial. J Clin Oncol. 2018 Nov 20:JCO1800896. doi: 10.1200/JCO.18.00896. (唯一通讯,IF:28.245)

2. Cheng J#, Korte N#, Nortley R, Sethi H, Tang Y*(唐亚梅), Attwell D*.Targeting pericytes for therapeutic approaches to neurological disorders. Acta Neuropathol. 2018 Aug 10. (Review)(并列通讯,IF:18.174)

3. Peng Y#, Lu K#, Li Z, Zhao Y, Wang Y, Hu B, Xu P, Shi X, Zhou B, Pennington M, Chandy KG, Tang Y*(唐亚梅). Blockade of Kv1.3 channels ameliorates radiation-induced brain injury. Neuro Oncol. 2014,16(4):528-39.(唯一通讯,IF:10.091)

4. Xu Y#, Rong X#, Hu W#, Huang X, Li Y, Zheng D, Cai Z, Zuo Z, Tang Y*(唐亚梅).Bevacizumab Monotherapy Reduces Radiation-induced Brain Necrosis in Nasopharyngeal Carcinoma Patients: A Randomized Controlled Trial. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1087-1095.(唯一通讯,IF:6.203)

5. Li Y#, Huang X#, Jiang J#, Hu W, Hu J, Cai J, Rong X, Cheng J, Xu Y, Wu R, Tang Y*(唐亚梅). Clinical Variables for Prediction of the Therapeutic Effects of Bevacizumab Monotherapy in Nasopharyngeal Carcinoma Patients With Radiation-Induced Brain Necrosis, Int J Radiat Oncol Biol Phys, 2018.3.1, 100(3): 621~629. (唯一通讯,IF:6.203)

6. Xu P#, Xu Y#, Hu B, Wang J, Pan R, Murugan M, Wu L, Tang Y*(唐亚梅). Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor. Brain Behav Immun. 2015 Nov; 50:87-100. (唯一通讯,IF:6.170)

7. Shen Q #, Lin F#, Rong X#, Yang W, Li Y, Cai Z, Xu P, Xu Y, Tang Y*(唐亚梅).Temporal Cerebral Microbleeds Are Associated With Radiation Necrosis And Cognitive Dysfunction In Patients Treated For Nasopharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1113-20. (唯一通讯,IF:6.203)

8. Li H#, Pan R#, Wang H, Rong X, Shi X, Yin Z, Tang Y*(唐亚梅), Peng Y*. Clipping vs. Coiling for Ruptured Intracranial Aneurysms: A Systematic Review and Meta-Analysis. Stroke. 2013;44(1):29-37.(并列通讯,IF:6.085)

9. Cai J#, Cheng J#, Li H#, Lin W, Li Y, Zhuo X, Huang X, Simone CB, Aronow WS, Chow E, Tang Y* (唐亚梅). A Nomogram for the Prediction of Cerebrovascular Disease among Patients with Brain Necrosis after Radiotherapy for Nasopharyngeal Carcinoma. Radiotherapy and Oncology. 2018 Dec. Article in Press. (唯一通讯,IF:5.252)

10. Zhuo X#, Huang X#, Yan M#, Li H, Li Y, Rong X, Lin J, Cai J, Xie F, Xu Y, Chen K, Tang Y*(唐亚梅). Comparison between high-dose and low-dose intravenous methylprednisolone therapy in patients with brain necrosis after radiotherapy for nasopharyngeal carcinoma. Radiother Oncol. 2019 Apr 29;137:16-23.(唯一通讯,IF:5.252)

11. Zheng B#, Lin J#, Li Y, Zhuo X, Huang X, Shen Q, Tang Y*(唐亚梅). Predictors of the therapeutic effect of corticosteroids on radiation-induced optic neuropathy following nasopharyngeal carcinoma. Supportive Care in Cancer. 2019 Feb. Articles in press(唯一通讯,IF:2.676)

12. Li H#, LI L#, Huang X#,Li Y, Zou T, Zhuo X, Chen Y, Liu Y*, Tang Y*(唐亚梅). Radiotherapy-induced dysphagia and its impact on quality of life in patients with nasopharyngeal carcinoma. StrahlentherOnkol. 2019 Jan 28. (共同通讯,IF:2.717)

13. Rui Pan, Jinping Cheng, Kelin Lai, Qing Huang, Hui Wu, Tang Y*(唐亚梅) Efficacy and Safety of Prothrombin Complex Concentrate for Vitamin K Antagonists-associated Intracranial Hemorrhage: A Systematic Review and Meta-analysis. Neurol Sci. 2019 Jan 28. (唯一通讯,IF:2.484)

14. Xu Y#, Hu W#, Liu Y#, Xu P, Li Z, Wu R, Shi X, Tang Y*(唐亚梅). P2Y6 receptor-mediated microglial phagocytosis in radiation-induced brain Injury. Mol Neurobiol. 2016 Aug;53(6):3552-64.(唯一通讯,IF:4.586)

15. Fu R#, Shen Q#, Xu P, Luo J, Tang Y*(唐亚梅). Phagocytosis of Microglia in the Central Nervous System Diseases. Mol Neurobiol. 2014;49(3):1422-34. (Review) (唯一通讯,IF:4.586)

16. Wu R #, Li X #, Xu P, Huang L, Cheng J, Huang X, Jiang J, Long-Jun Wu, Tang Y* (唐亚梅). TREM2 protects against cerebral ischemia/reperfusion injury. Molecular Brain. 2017,10(1):20. (唯一通讯,IF:4.051)

17. Tang Y#*(唐亚梅), Rong X#, Hu W, Li G, Yang X, Yang J, Xu P, Luo J. Effect of edaravone on radiation-induced brain necrosis in patients with nasopharyngeal carcinoma after radiotherapy: a randomized controlled trial. J Neurooncol 2014,120(2):441-447.(唯一通讯,IF:3.129)

18. Li H#, Yao Q#, Huang X, Zhuo X, Lin J, Tang Y*(唐亚梅).Therapeutic effect of pregabalin on radiotherapy-induced trismus in nasopharyngeal carcinoma patients. European Annals of Otorhinolaryngology. 2018 Dec. Articles in press(唯一通讯,IF:1.03)

19. Wang H#, Tang Y#(唐亚梅), Rong X, Li H, Pan R, Wang Y, Peng Y*. Effects of early blood pressure lowering on early and long-term outcomes after acute stroke: an updated meta-analysis. PloS ONE. 2014;9(5):e97917.(并列第一,IF:2.776)

20. Ye J#, Rong X#, Xiang Y, Xing Y, Tang Y*(唐亚梅). A Study of Radiation-induced Cerebral Vascular Injury in Nasopharyngeal Carcinoma Patients with Radiation-induced Temporal Lobe Necrosis. PloS ONE. 2012,7(8): e42890.(唯一通讯,IF:2.776)

21. Tang Y*(唐亚梅), Luo D, Rong X, Shi X, Peng Y. Psychological Disorders, Cognitive Dysfunction and Quality of Life in Nasopharyngeal Carcinoma Patients with Radiation-induced Brain Injury. PloS ONE. 2012,7(6):e36529. (唯一通讯,IF:2.776)

22. Li Y#, Shi X, Rong X, Peng Y, Tang Y#*(唐亚梅). Neurosurgery and prognosis in patients with radiation-induced brain injury after nasopharyngeal carcinoma radiotherapy: a prospective study. Radiation Oncology. 2013, 8:88. (唯一通讯,IF:2.895)

23. Tang Y#*(唐亚梅), Li Y#, Luo D, Rong X, Ye J, Peng Y. Epilepsy related to radiotherapy in patients with nasopharyngeal carcinoma. Epilepsy Res.2011;96:24-28. (唯一通讯,IF:2.178)

24. Rong X#, Tang Y#*(唐亚梅), Chen M, Lu K, Peng Y. Radiation-induced cranial neuropathy in patients with nasopharyngeal carcinoma: a follow-up study. StrahlentherOnkol. 2012,188(3):282-6.(唯一通讯,IF:2.717)

25. Tang Y*(唐亚梅), Shen Q, Wang Y, Lu K, Wang Y, Peng Y*. A Randomized Prospective Study of Rehabilitation Therapy in the Treatment of Radiation-induced Dysphagia and Trismus. StrahlentherOnkol. 2011;187(1):39-44.(并列通讯,IF:2.717)

26. Tang Y#*(唐亚梅), Zhang Y#, Guo L, Peng Y, Luo Q, Xing Y. Relationship between individual radiosensitivity and radiation encephalopathy of nasopharyngeal carcinoma after radiotherapy. StrahlentherOnkol. 2008; 184:510-514. (唯一通讯,IF:2.717)

27. Tang Y#(唐亚梅), Yasuhara T#, Hara K, Matsukawa N, Maki M, Yu G, Xu L, Hess DC, Borlongan CV*. Transplantation of bone marrow-derived stem cells: a promising therapy for stroke. Cell Transplant. 2007;16(2):159-69. (Review)(并列第一,IF:3.477)

28. Tang Y#(唐亚梅), Saul A*, Gur M. Goei S, Wong E, Ersov B, Snodderly DM. Eye position compensation improves estimates of response magnitude and receptive field geometry in alert monkeys. J. Neurophysiol. 2007 ;97(5):3439-48. (第一作者,IF:2.614)

29. Li Q, Tang Y*(唐亚梅), Liu J, Zhou D, li X, Xiao S, Jian D, Xing Y*. Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene. Synapse. 2007 ;61(12):971-7. (并列通讯,IF:2.545)

30. Liu W*, Tang Y*(唐亚梅), Feng J. Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system. Life Sci. 2011 Aug 1;89(5-6):141-6. (Review) (并列通讯,IF:3.448)

31. Tang Y*(唐亚梅), Luo D., Huang F., Peng W., Peng Y. Ocular Ischemic Syndrome Secondary to Carotid Artery Occlusion as a Late Complication of Radiotherapy of Nasopharyngeal Carcinoma. J Neuro-Ophthalmol. 2010; 30,(4):315-320. (唯一通讯,IF:2.152)

32. Yang L#, Yang J#, Li G#, Li Y, Wu R, Cheng J, Tang Y*(唐亚梅). Pathophysiological Responses in Rat and Mouse Models of Radiation-Induced Brain Injury. Mol Neurobiol. 2017 Mar;54(2):1022-1032(唯一通讯,IF:4.586)

33. Li H#, Zheng D#, Xie F, Huang X, Zhuo X, Lin J, Li Y, Tang Y*(唐亚梅). The correlation between serum apolipoprotein B/apolipoprotein A1 ratio and brain necrosis in patients underwent radiotherapy for nasopharyngeal carcinoma. BRAIN BEHAV 2020:e1554. (唯一通讯,IF: 2.072)

四、会议交流

1. Society for Neuroscience, the 49th annual meeting. Chicago, U.S.A.,2019. Oral presentation: Immune-neuron interaction in radiation-associated cognition dysfunction.

2. Society for Neuroscience, the 46th annual meeting. San Diego, U.S.A.,2016. Oral presentation: TREM2 protects against cerebral ischemia/reperfusion injury.

3. Society for Neuroscience, the 44th annual meeting. Washington DC, U.S.A.,2014. Oral presentation: Phagocytosis of Microglia in radiation induced brain injury.

4. CSH-Asia, Novel Insights into Glia Function & Dysfunction, 2018. Suzhou, China. Oral presentation: TREM2 protects against cerebral ischemia/reperfusion injury

5. CSH-Asia, Novel Insights into Glia Function & Dysfunction, 2016. Suzhou, China. Oral presentation: Pericyte degeneration impairs capillary reflow in radiation induced braiinjuryβ

6. Asia Pain Summit, the 8th annual meeting. Bangkok, Thailand, 2013. Host and oral presentation: Postherpetic Neuralgia: Diagnosis and Treatment.

7. Federation of European Neuroscience Society, the 7th Annual Forum, 2010. Amsterdam, the Netherlands. Poster: Microglia Kv1.3 channels as a therapeutic target for radiation induced brain injury.(海报交流:获大会优秀青年学者旅行资助奖励)

8. NABIS Conference on Brain Injury, the 7th annual meeting. 2009. Austin Texas, USA. Oral presentation: Specific kv1.3 blocker acts as a novel therapeutic strategy in irradiation induced brain injury.

9. 第十八次全国神经病学学术会议, 2015年,中国成都,小胶质细胞旁分泌功能在放射性脑损伤发病机制中的研究.(大会优秀论文奖)

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